Our lab investigates synaptic transmission at the level of its basic unit: single synapses

 

We are curious about the molecular organization and signaling pathways that determine the properties of synapses and how these dynamically change (temporally and spatially) in response to neuron activity, external signals and degenerative processes

 

Super-resolution images of presynaptic terminals and synaptic vesicles

Although our love for synapses is broad, we are currently focused on two research programs: modulation of neurotransmission by calcium signals triggered by the stores; and neuron communication via extracellular vesicles.

Live fluorescence imaging of calcium and glutamate at dendrites during neuron firing

Is it the moon??

Just our view through the microscope while patching neurons!!

Whole cell voltage clamp electrophysiology of basal neurotransmission: positive peaks are currents triggered by GABA, negative currents are driven by glutamate

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University of Pennsylvania - Perelman School of Medicine -- https://www.med.upenn.edu/

Department of Physiology -- https://www.med.upenn.edu/physiol

Cell and Molecular Biology Graduate Group (CAMB) -- https://www.med.upenn.edu/camb/

Neuroscience Graduate Group (NGG) -- https://www.med.upenn.edu/ngg/