Our lab investigates synaptic transmission at the level of its basic unit: Synapses

 

But synapses do not exist in the void, they are in constant, dynamic exchange with neuronal organelles, including the endoplasmic reticulum, the Golgi apparatus and related structures, trafficking vesicles and extracellular vesicles.

Our long term goal is to understand how neuronal organelles shape the efficacy and plasticity of synapses.

 

Super-resolution images of presynaptic terminals and synaptic vesicles

We are interdisciplinary group - we combine our talents in chemistry, molecular biology, microscopy and physiology to generate new tools to study neurons and answer fundamental questions about the mechanisms regulating synaptic transmission.

Live fluorescence imaging of calcium and glutamate at dendrites during neuron firing

Is it the moon??

Just our view through the microscope while patching neurons!!

Whole cell voltage clamp electrophysiology of basal neurotransmission: positive peaks are currents triggered by GABA, negative currents are driven by glutamate

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University of Pennsylvania - Perelman School of Medicine -- https://www.med.upenn.edu/

Department of Physiology -- https://www.med.upenn.edu/physiol

Cell and Molecular Biology Graduate Group (CAMB) -- https://www.med.upenn.edu/camb/

Neuroscience Graduate Group (NGG) -- https://www.med.upenn.edu/ngg/

Biochemistry, Biophysics, Chemical Biology (BBCB) -- https://www.med.upenn.edu/bmbgrad/